Yes, EP configuration has a setting called as ‘Subject Filter’ under Inclusion section.
Here you can add multiple keywords seperated by “;”. If this filter has been specified then email subject having any of these matching keywords would be processed and rest will be ignored. If no values have been specified then no filteration will be applied.

eg. keyword: @case
Only emails having subject “@case” will be processed for the particular configuration.

This allows you to have same queue but multiple configurations…eg. you could setup a support queue and 2 different configuartion records… one for creating leads and other one for creating cases. In the lead configuration…the keyword could be @lead and in case configuration… the keyword could be @case.